APPLICATIONS
Anterior to Posterior
Pole to Periphery
Retinal Morphology and Dystrophy
Evaluating the layers of the retina to study inherited retinal diseases (IRDs) or progressive rod-cone degenerations. OCT objectively measures layer thickness, allowing researchers to quantify photoreceptor loss and degeneration.
Chemical damage to outer retina in mouse model; OCT scan taken in EDI (Enhanced Depth Imaging) mode.
Glaucoma and Optic Nerve Assessment
Monitoring the thickness of the Retinal Nerve Fiber Layer (RNFL) and morphological changes in the optic nerve head in experimental animal models with artificially elevated intraocular pressure (IOP).
Thin C-slice projection of anesthetized NHP optic nerve head OCT image (left) showing the en face view (right) of the lamina cribrosa imaged with the Envisu R4310 VHR. CHECK WITH JOE P ABOUT USING ONE OF THEIR IMAGES?
Anterior Segment Imaging (AS-OCT)
Visualizing the cornea, anterior chamber, and iridocorneal angle. OCT is used to study corneal wound healing, track responses to osmotic stress, and evaluate the efficacy of topical drug delivery.
Horse anterior chamber OCT scan using the Envisu R2210 VHR. Post op of a posterior lamellar keratoplasty showing a detachment of Decemet's membrane and anterior synechia.
Ocular Inflammation (Uveitis)
Quantifying inflammatory cells, assessing flare within the anterior chamber, and evaluating uveitis in rabbit and rodent models.
Mouse model of endotoxin induced uveitis, 36hrs post injection. OCT image taken with Envisu R2200 UHR.
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OCT Angiography (OCT-A)
Providing depth-resolved, motion-contrast imaging of retinal and choroidal microvasculature without the need for invasive dye injections. This is instrumental in assessing animal models of laser-induced choroidal neovascularization (CNV).
Tree Shrew OCT image acquired with Envisu R2210 specifically for Angiography post processing using LighTopTech's 4D Viewer and Octava quantification software.
Toxicological Screening
Serving as a structural endpoint for preclinical drug safety and toxicology, eliminating the need to euthanize large cohorts of animals for traditional histology. Accelerate research by imaging early and often, where high optical quality of the eye is retained to exploit the resolution and capabilities of the imaging system.
Minimally invasive OCT scans serve to show real time optical histology of disease progression and treatment.